Which X-linked genetic condition results in accumulation of lipids throughout the body?

• A. Gaucher disease
• B. Niemann-Pick disease
• C. Hunter syndrome
• D. Anderson-Fabry disease

Answer: (D)

This question tests an X-linked lysosomal storage disorder where lipid (glycolipid) buildup occurs throughout many tissues. Anderson-Fabry disease results from deficiency of alpha-galactosidase A, causing accumulation of globotriaosylceramide in the vascular endothelium and various organs. This widespread lipid storage explains systemic manifestations such as vascular symptoms, kidney and heart involvement, and neuropathic pain.

Gaucher disease is autosomal recessive and involves glucocerebroside buildup in macrophages, not a general lipid accumulation along the body. Niemann-Pick disease also involves lipid storage (sphingomyelin) but is autosomal recessive. Hunter syndrome is X-linked but stores glycosaminoglycans, not lipids. Therefore, the X-linked condition with broad lipid accumulation is Anderson-Fabry disease.