Which statement best describes the basic pathophysiology of metabolic syndrome?

• A. Hyperinsulinemia, hypertension, obesity lead to endothelial dysfunction and vascular inflammation, promoting atherosclerosis and hyperglycemia
• B. Hypoinsulinemia leads to reduced insulin resistance and less inflammation
• C. Endothelial health improves with weight loss
• D. Elevated LDL directly causes plaque without inflammation

Answer: (A)